Afzelin

Afzelin can be described as a glycosyloxyflavone. It is composed of kaempferol and an alpha-L–rhamnosyl residue located at position 3. It is done via a glycosidic linking. It serves as an antibacterial, antibacterial, and anti-inflammatory plant metabolite. It is a glycosyloxyflavone. It comes from kaempferol. It is a conjugate amino of an afzelin (1-). There are many chemical stores from where you can buy chemicals. You can visit the most trusted ones and can order your required one for research and for other purpose. Buy chemicals online and afzelin from different vendors. These chemicals can also be searched on different online stores.

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

MeSH Entry Terms

Afzelin

deacyl-SL0101

kaempferol-3-O-alpha-L-rhamnoside

kaempferol-3-rhamnoside

  • Molecular Formula C21H20O10
  • Average mass 432.378 Da
  • Monoisotopic mass 432.105652 Da
Synonyms Afzelin 482-39-3 kaempferol-3-rhamnoside Kaempferin Kaempferol 3-rhamnoside

Properties

Property NameProperty ValueReference
Molecular Weight432.4Computed by PubChem 2.1 (PubChem release 2021.05.07)
XLogP3-AA1.2Computed by XLogP3 3.0 (PubChem release 2021.05.07)
Hydrogen Bond Donor Count6Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Hydrogen Bond Acceptor Count10Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Rotatable Bond Count3Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Exact Mass432.10564683Computed by PubChem 2.1 (PubChem release 2021.05.07)
Monoisotopic Mass432.10564683Computed by PubChem 2.1 (PubChem release 2021.05.07)
Topological Polar Surface Area166 ŲComputed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Heavy Atom Count31Computed by PubChem
Formal Charge0Computed by PubChem
Complexity702Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Isotope Atom Count0Computed by PubChem
Defined Atom Stereocenter Count5Computed by PubChem
Undefined Atom Stereocenter Count0Computed by PubChem
Defined Bond Stereocenter Count0Computed by PubChem
Undefined Bond Stereocenter Count0Computed by PubChem
Covalently-Bonded Unit Count1Computed by PubChem
Compound Is CanonicalizedYesComputed by PubChem (release 2021.05.07)

General description

Afzelin is a natural product made from plant material. The Ficus palate is the most crucial source of afzelin. Nymphaea or atom is the primary source.

Application

Afzelin has antibacterial, DNA-protective, and antioxidant properties. Afzelin can be detected in HPLC (high-performance liquid chromatography) analysis Comarum PalustreL. Extract.

Antibacterial, DNA-protective, and antioxidant.

Biochem/Physiol Actions

Afzelin has been shown to have antibacterial, anti-inflammatory, and anti-tumor activity. Therefore, Afzelin could be used to treat P.aeruginosa-related disorders. Afzelin can also be used to promote apoptosis and inhibit breast cancer cell proliferation. In addition, it has anti-asthmatic activity in a mouse model.

Afzelin, kaempferol 3O-rhamnoside and kaempferol 3O-rhamnoside both belong to the flavonol sugar group. Afzelin can be found in 56 plants. It has been found in 56 plants, making it easily accessible. 15 It was demonstrated that afzelin inhibits Rac1–GTPase activation and reduced focal adhesionkinase (FAK), but the target proteins have yet to be identified.

Results

GalN/LPS treated mice with Afzelin had a greater survival rate and lower serum levels of pro-inflammatory and cytokines. Afzelin decreased mitochondrial swelling in GalN/LPS mice and increased mitochondrial glutamate dehydrogenase activity. Afzelin promoted mitochondrial biogenesis. This was evident by increased PPAR-g activator 1a, nuclear Respir factor 1, and mitochondrial transcript factor A. Afzelin also reduced the levels of mitophagy related proteins, parkin, and PTEN-induced kinase 1. GalN/LPS increased the levels of dynamin-related protein one and dynamin-related prot1, respectively, but these effects were reduced by afzelin.

Afzelin is a natural flavonol glycoside flavonol product that’s derived from Kaempferol. It contains four hydroxy group positions 3, 5, 7, and 4 on the flavone. The afzelin is created by forming a glycosidic bond between the 3-O-atom of Kaempferol and a-L–rhamnose. This results in the presence of 3 phenol and five stereogenic centers. Afzelin was recently evaluated for its biological properties. It has been shown to have antibacterial activity and high aldose reductase inhibitory activities.

In conclusion, the central administration of afzelin ameliorates scopolamine-induced cognitive impairment in the brain. These effects of afzelin might be related to restored cholinergic dysfunction, enhanced LTP, and an increase of BDNF/CREB signaling.

Conclusions

Our findings showed that afzelin protects liver injury from GalN/LPS by stimulating mitochondrial biogenesis, suppressing excess mitophagy, and balancing the mitochondrial dynamics. Afzelin decreases mitochondrial damage, improves mitochondrial biogenesis, reduces mitophagy-related proteins, parkin, as well as the levels of PTEN-induced putative kinase 1. In addition, Afzelin reduces the mortality rate and serum levels of pro-inflammatory and cytokines in D.-galactosamine/LPS-treated mice.

By David Jason

Chemical Engineer

Leave a Reply